Newly Formed Variants Infect Cells Rapidly

newly formed variants infect cells quickly
newly formed variants infect cells quickly

Stating that the newly formed variants make their dangerous properties even more effective, experts point out that they infect cells faster.

Üsküdar University Faculty of Engineering and Natural Sciences Molecular Biology and Genetics Instructor Prof. Dr. Korkut Ulucan made evaluations on the variants of the coronavirus that have affected the whole world for more than a year.

Stating that the pandemic of the century, which started in Wuhan, China as of the end of 2019, affected the whole world in a short time. Dr. Korkut Ulucan said, “The pandemic has completely changed the rules of the world. Pandemic is still on our agenda with news of new variants and suddenly increasing deaths. What are these variants and how are they so dangerous? said.

Virus analyzed with genetic studies

Noting that after it was determined that the cause of the disease was the virus, Prof. Dr. Korkut Ulucan said, “Thus, we have gained a lot of information about the genetic structure of the virus. We have acquired very important information about what information is hidden in which parts, the metabolism in the cell and the cell entrance, and the content of the genetic structure that governs these metabolisms. This information actually provided scientists with very important information both for the treatment of the disease and for vaccine studies. In this way, vaccine studies accelerated. kazanwas.” He talked about the importance of scientific developments.

Viruses reproduce themselves in the host cell

Prof. Dr. Korkut Ulucan made the following evaluations regarding the virus creating too many variants:

“Viruses are also considered as obligate intracellular parasites, ie they only activate themselves in another cell. After entering the host cell, they either integrate their own genome into the host cell genome, or they tend to infect other cells by rapidly replicating themselves and killing the host cell, ”he said.

The newly formed variants are more effective

During rapid reproduction, they sometimes make mistakes while synthesizing their genomes. These errors also add a new feature to viruses. kazanThey either increase the effect of an existing feature or cause the effect of an existing feature to disappear. Here, the newly formed variants make their properties even more effective when they pose a threat to us, infecting cells faster.” said.

Noting that these variants proliferate very rapidly due to these features, Prof. Dr. Korkut Ulucan said, “They become a dominant variant in a certain region over time and increase the speed and risk of infection. Therefore, characterization of the variants formed is very important. "The more viruses enter the host cell, the more they are open to change and the more dangerous they reach for us," he drew attention to the danger of variants.

The increase in the number of deaths is proportional to the variants that occur

Prof. Dr. Korkut Ulucan said the following regarding the increase in the number of deaths:

“The more easily viruses enter the cells, the more numerical they reach, and they can cause undesirable consequences, especially in sensitive individuals, meaning that a virus can easily enter the cell, infect more individuals with new variants, and thus cause more serious damage to individuals who cannot resist the virus. can come. Therefore, the hypothesis that new variants have a high risk of infection but a low mortality rate is not always correct. Here, the genetic structures of infected individuals and the strength of their immune systems are also important, that is, the resistance of the host cell and the infected individuals against the virus, and the biological and genetic structure underlying this resistance are very important.

Prof. Dr. Korkut Ulucan noted that the mortality rates are not only dependent on the virus, but are linked to the genetic and biological structure of the individual.

There is also the possibility that newly formed and potential variants are fusions.

Stating that the more the virus infects, the more it invites change. Dr. Korkut Ulucan concluded his words as follows:

“The errors that can occur when copying the virus's own genome, which we currently predict, and either new features resulting from these errors. kazanma or variations that strengthen a trait. At first, we compared it with influenza, and we thought whether the different variants we observed in influenza could combine in a cell and form a new and dangerous variant. Our current information is not in this direction, but for now, for example, the common points of the previous variants in the Indian virus, which scares us now, led us to think like this. We already have the information at hand, that all variants are derived from the original SARS-CoV-2 and there is a high probability of finding common regions, but in time, we will be able to understand more clearly whether different variants infect a cell and form new gene combinations within the cell. It is too early to claim this, but it should be noted that just as new variants show more severe features in the virus, variants that lose their characteristics are also formed, and perhaps the proliferation of these variants will speed up vaccination studies. kazanMaybe we will be able to get rid of this virus if it is dead and we leave the virus without a host cell more carefully. That's why we should continue to pay attention to the distance, mask, ventilation and hygiene quartet until there are zero cases.

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